BMI, calculator, energy needs, caloric needs, calorie needs, adult




Synopsis of Research on the Waist-Height Ratio

Preventive Medicine

A study in the February 2005 issue of Preventive Medicine looked at the superiority of the waist-to-height ratio as an anthropometric index to evaluate clustering of coronary risk factors among non-obese men and women. Researchers compared BMI, waist circumference, and waist-to-height ratios for 4,668 men and 1,853 women with a BMI < 25 as indices for estimating coronary risk factors. The researchers found that the sum of all coronary risk factors correlated positively with all the indexes, with the closest correlation found for waist-to-height ratios. Among the various proposed indexes the evaluation of risk factors were highest for a waist-to-height ratio greater than 0.5000. They concluded that waist-to-height ratio is more sensitive than BMI or waist circumference alone to evaluate coronary risk factors among non-obese men and women (Hsieh, S. D., et al, 2005: 216-220).

American Journal of Clinical Nutrition

A 2002 study in the American Journal of Clinical Nutrition, indicates that "a cross-sectional study, which supports the consistent conclusion from a large body of literature that waist circumference (WC) is at least as strong as is a body mass index (BMI) in predicting cardiovascular disease" (Lean, 2002:699). The report goes on to claim that men with a WC > 94 cm and women with a WC > 80 cm would virtually identify anyone with a BMI > 25. While a WC > 102 cm for men and > 88 cm for women would identify everyone with a BMI > 30. This study correlates well with the Air Forces decision to drop the Weight and Body Fat Management Program and rely on WC measures as a means of determining one's health.

Public Health and the Environment

In the November 2003 issue of Public Health and the Environment, Dr. Henry Kahn and others determined that a waist-to-height ratio is a good predictor of BMI. Regardless of sex and age, his cross-sectional, weighted sample estimated the risk factors as high if one's waist-to-height ratio was greater than 0.543 and only moderate between 0.498 and 0.543 (Kahn, 2003).

Japanese Journal of Clinical Medicine

A study in the Nippon Rinsho: Japanese Journal of Clinical Medicine looked at various anthropometric indices (BMI, waist circumference, and waist-to-height ratio) to find a simple method for assessing the risk of metabolic syndrome. Waist-to-height ratios correlated more closely than any other index to the sum of 4 or 5 coronary risk factors. A waist-to-height index greater than 0.5000 was capable of identifying approximately all overweight individuals and also identified more individuals of normal weight as at risk than any other measure of central fat distribution.

Even normal-weight subjects with a waist-to-height ratio greater than 0.5000 demonstrated significantly higher risk for 2 or more coronary risk factors than those individuals with a waist-to-height ratio less than 0.5000 (Hsieh, Shiun Dong and Takashi Muto, 2004: 1143-1149).

International Journal of Obesity

A study in the November 2000 issue of International Journal of Obesity, etc.*determined waist-to-height ratios are a better predictor of cardiovascular disease in children than BMI. Waist-to-height ratios have been used as a proxy measure of visceral adipose tissue, mainly in adults. The objective was to validate BMI, waist circumference and waist-to-height ratio as predictors for the presence of cardiovascular risk factors in children. Their conclusions were that waist circumference and waist-to-height ratios are better predictors of cardiovascular disease in children than BMI (Savva et al, 2000: 1453-1458).

A second study in the November 2002 issue of International Journal of Obesity, etc. determined the optimal cut-off values of four anthropometric indices (BMI, waist circumference, waist-to-hip ratio, and waist-to-height ratio) to estimate cardiovascular disease risk factors.

Data was collected on 26,359 Asian men and 29,204 Asian women with a mean age of 37. Individual body weight, height and waist circumference and a series of tests related to cardiovascular risk were assessed and their relationships were examined. Of the four indices studied, waist-to-height ratios were found to have the largest areas under the curve relative to at least one risk factor. The conclusions are that waist-to-height ratios may be a better indicator for screening overweight or obesity-related cardiovascular disease risk factors than the other three indexes (BMI, waist circumference, and waist-to-hip ratio) The optimal cut off values for overweight or obesity waist-to height ratios were 0.4800 for men and 0.4500 for women (Lin, W. Y.,et al, 2002: 1232-1238).

In the May 2003 issue of International Journal of Obesity, etc., researchers hypothesized that the waist-to-height ratio can be used to identify subjects who are at higher metabolic risk within the normal as well as the overweight range. The researchers compared the values for BMI, waist circumference, and waist-to-height ratios for 6141 men and 2137 women at various age levels.

The researchers found that for various indexes in all age groups; the gender ratio for waist-to-height was closest to 1. They determined that a single set of values for waist-to-height ratios can be used for men and women. For both men and women, the highest correlation coefficient was between waist-to-height ratio and the morbidity index for coronary risk factors. Nearly all overweight men and women (BMI > 25) had waist-to-height ratios > 0.5000 (98% of men and 97.5% of women). The conclusions are that waist circumference is improved by relating it to height to categorize fat distributions of different genders and ages (Hsieh, S. D., et al, 2003: 610-616).


*(The full name of the publication is International Journal of Obesity and Related Metabolic Disorders: Journal of the International Association for the Study of Obesity).


Research on Salt Intake (sodium chloride or table salt, and potassium salts (primarily potassium chloride))

Primary Prevention of Ischemic Stroke: A Guideline from the Stroke Council of the American Heart Association/American Stroke Association

Published online May 4, 2006, and available for free on The American Heart Assoc. website.

The AHA's stroke prevention team takes what would appear to be a safe approach to stroke prevention and salt intake: "People with high blood pressure should increase their intake of potassium and decrease the amount of salt they eat to reduce their blood pressure — along with medications prescribed by their physicians."

Research on poplyphenols, especially flavonoids — food content and benefits

  1. Cao, G. H., Sofic, E., and Prior, R. L. (1996) Antioxidant capacity of tea and common vegetables. Journal of Agricultural and Food Chemistry 44, 3426-3431.
  2. Wang, H., Cao, G. H., and Prior, R. L. (1996) Total antioxidant capacity of fruits. Journal of Agricultural and Food Chemistry 44, 701-705.
  3. Paganga,G.; Miller,N.; Rice-Evans,C.A. (1999) The polyphenolic content of fruit and vegetables and their antioxidant activities. What does a serving constitute? Free Radic.Res. 30, 153-162.
  4. Miller, N. J., Rice-Evans, C., Davies, M. J., Gopinathan, V., and Milner, A. (1993) A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin.Sci.(Colch.) 84, 407-412.
  5. Jovanovic, S. V., Steenken, S., Hara, Y., and Simic, M. G. (1996) Reduction potentials of flavonoid and model phenoxyl radicals. Which ring in flavonoids is responsible for antioxidant activity? Journal of the Chemical Society-Perkin Transactions 2 2497-2504.
  6. Shim, J. S., Kang, M. H., Kim, Y. H., Roh, J. K., Roberts, C., and Lee, I. P. (1995) Chemopreventive effect of green tea (Camellia sinensis) among cigarette smokers. Cancer Epidemiol.Biomarkers Prev. 4, 387-391.
  7. Xue, K. X., Wang, S., Ma, G. J., Zhou, P., Wu, P. Q., Zhang, R. F., Xu, Z., Chen, W. S., and Wang, Y. Q. (1992) Micronucleus formation in peripheral-blood lymphocytes from smokers and the influence of alcohol- and tea-drinking habits. Int J Cancer 50, 702-705.
  8. Klaunig, J.E., et al. The effect of tea consumption on oxidative stress in smokers and nonsmokers. Proceedings of the Society for Experimental Biology and Medicine. 220; 4:249-254, April 1999.
  9. Klaunig, 2001, personal communication.
  10. Merken H.M., Beecher G.R. (2000) “ Liquid chromatographic method for the separation and quantification of prominent flavonoid aglycones” J. Chromatog. 897, 177-184
  11. Clifford M (1999) “A Nomenclature for Tea Phenols” in ILSI Proceedings on “The Health Effects of Tea Components” Washington, DC, USA.
  12. Engelhardt U.H. et al (1992) “Determination of Flavonol Glycosides in Black Tea” Dtsch. Lebensm. Rundsch. 88, 69-73
  13. Engelhardt, U.H., Finger, A., Kuhr, S. “Determination of fla-vone-C-gly-cosides in tea". Z. Lebensm. Unters. Forsch., 1993, 197, 239-244
  14. Kiehne et al (1997) “Analysis of Proanthocyanidins in Tea Samples” Z. Lebensm. Unters. Forsch. 207, 153 – 157
  15. Lakenbrink C. (2000) PhD Thesis, Technische Universitaet Braunsschweig, Germany
  16. Roberts E.A.H., Myers M. (1958) “The Phenolic Substances of Manufactured Tea” J Sci Food Agric 9, 701
  17. Roberts E.A.H., (1958) “The Phenolic Substances of Manufactured Tea” J Sci Food Agric 9, 212 – 216
  18. Bailey et al (1991) “Comparative Study of RP-HPLC of Black tea Liquors with Special Reference to the Thearubigins” J. Chromatogr. 542, 115 – 128
  19. Degenhardt A. et al (2000) “Isolation of black tea Pigments Using HSCCC and Studies on Properties of Black tea polymers” J. Agric. Food Chem. 48, 5200 – 5205
  20. Bailey et al (1994) Isolation and HPLC of Thearubigin Fractions from Black Tea” J. Chromatogr. 662, 101 – 112
  21. Bailey et al (1994) “ A Comparison of the HPLC, Mass Spectra, and Acid Degradation of Theafulvins from Black Tea and the Proanthocyanadin polymers from Wine and Cider” J. Sci. Food. Agric. 64, 231 – 238
  22. Ozawa T. et al (1996) “Elucidation of the partial structure of polymeric thearubigins from black tea by chemical degradation” Biosci., Biotech., Biochem. 60, 2023 – 2027
  23. Maxwell, S. and Thorpe, G. (1996) Tea flavonoids have little short term impact on serum antioxidant activity. British Medical Journal 313, 229.
  24. McAnlis, G. T., McEneny, J., Pearce, J., and Young, I. S. (1998) Black tea consumption does not protect low density lipoprotein from oxidative modification. Eur.J Clin.Nutr. 52, 202-206.
  25. van het Hof, K. H., de Boer, H. S., Wiseman, S. A., Lien, N., Westrate, J. A., and Tijburg, L. B. (1997) Consumption of green or black tea does not increase resistance of low-density lipoprotein to oxidation in humans. Am.J.Clin.Nutr. 66, 1125-1132.
  26. Benzie, I. F., Szeto, Y. T., Strain, J. J., and Tomlinson, B. (1999) Consumption of green tea causes rapid increase in plasma antioxidant power in humans. Nutr.Cancer 34, 83-87.
  27. Serafini, M., Ghiselli, A., and Ferro-Luzzi, A. (1996) In vivo antioxidant effect of green and black tea in man. Eur.J.Clin.Nutr. 50, 28-32.
  28. Serafini, M., Laranjinha, J. A., Almeida, L. M., and Maiani, G. (2000) Inhibition of human LDL lipid peroxidation by phenol-rich beverages and their impact on plasma total antioxidant capacity in humans. J Nutr.Biochem. 11, 585-590.
  29. Langley-Evans, S. C. (2000) Consumption of black tea elicits an increase in plasma antioxidant potential in humans. Int J Food Sci.Nutr. 51, 309-315.
  30. Sung, H., Nah, J., Chun, S., Park, H., Yang, S. E., and Min, W. K. (2000) In vivo antioxidant effect of green tea. Eur.J.Clin.Nutr. 54, 527-529.
  31. Hodgson, J. M., Puddey, I. B., Croft, K. D., Burke, V., Mori, T. A., Caccetta, R. A., and Beilin, L. J. (2000) Acute effects of ingestion of black and green tea on lipoprotein oxidation. Am.J.Clin.Nutr. 71, 1103-1107.
  32. Duffy, S. J., Keaney, J. F., Jr., Holbrook, M., Gokce, N., Swerdloff, P. L., Frei, B., and Vita, J. A. (2001) Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation 104, 151-156.
  33. Position Paper on Functional Foods. Journal of The American Dietetic Association. Volume 99 Number 10: 1278-1285, October 1999.
  34. Middleton, E. (1998) Effect of plant flavonoids on immune and inflammatory cell function. Flavonoids in the Living System 439, 175-182.
  35. Zvetkova E, Wirleitner B, Tram NT, Schennach H, Fuchs D. Int Immunopharmacol 2001 Nov;1(12):2143-50 Aqueous extracts of Crinum latifolium (L.) and Camellia sinensis show immunomodulatory properties in human peripheral blood mononuclear cells.
  36. Mabe, K., Yamada, M., Oguni, I., and Takahashi, T. (1999) In vitro and in vivo activities of tea catechins against Helicobacter pylori. Antimicrob.Agents Chemother. 43, 1788-1791. (animals)
  37. Matsunaga, K., Klein, T. W., Friedman, H., and Yamamoto, Y. (2001) Legionella pneumophila replication in macrophages inhibited by selective immunomodulatory effects on cytokine formation by epigallocatechin gallate, a major form of tea catechins. Infection and Immunity 69, 3947-3953.
  38. Isogai E, Isogai H, Hirose K, Hayashi S, Oguma K. Curr Microbiol 2001 Apr;42(4):248-51 In vivo synergy between green tea extract and levofloxacin against enterohemorrhagic Escherichia coli O157 infection.
  39. Sharquie KE, al-Turfi IA, al-Salloum SM. J Dermatol 2000 Nov;27(11):706-10 The antibacterial activity of tea in vitro and in vivo (in patients with impetigo contagiosa).
  40. Katiyar, S. K. and Mukhtar, H. (1997) Inhibition of phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate-caused inflammatory responses in SENCAR mouse skin by black tea polyphenols. Carcinogenesis 18, 1911-1916.
  41. Zhu, M. X., Gong, Y. F., Yang, Z. H., Ge, G. X., Han, C., and Chen, J. S. (1999) Green tea and its major components ameliorate immune dysfunction in mice bearing Lewis lung carcinoma and treated with the carcinogen NNK. Nutrition and Cancer-An International Journal 35, 64-72.
  42. Crouvezier, S., Powell, B., Keir, D., and Yaqoob, P. (2001) The effects of phenolic components of tea on the production of pro- and anti-inflammatory cytokines by human leukocytes in vitro. Cytokine 13, 280-286.
  43. Matsunaga, K., Klein, T. W., Friedman, H., and Yamamoto, Y. (2002) In vitro therapeutic effect of epigallocatechin gallate on nicotine-induced impairment of resistance to Legionella pneumophila infection of established MH-S alveolar macrophages. Journal of Infectious Diseases 185, 229-236.
  44. Sarkar, S., Sett, P., Chowdhury, T., and Ganguly, D.K. Effect of black tea on teeth. J Indian Soc Pedod Prev Dent 2000;18:139-140.
  45. Yu, H., Oho, T., Xu, L. X. Effects of several tea components on acid resistance of human tooth enamel. J Dent 1995;13:101-105.
  46. Berglund B & Hemmingsson P. “Effects of caffeine ingestion on exercise performance at low and high altitudes in cross country skiers”. Int J Sports Med 1982;3:234-6
  47. Costill DL, Dalsky GP, Fink WJ. “Effects of caffeine ingestion on metabolism and exercise performance”. Med Sci Sports 1978;10:155-8
  48. Cadarette et al ‘ Effects of varied doses of caffeine on endurance exercise to fatigue’. Biochem Exercise, 1983; 13,871
  49. Ferrauti A, Weber K, Struder HK. “Metabolic and ergogenic effects of carbohydrate and caffeine beverages in tennis”. J Sports Med Phys Fitness, 1997;37(4):258-66
  50. Ryu S, Choi SK, Joung SS, Suh H, Cha YS, Lee S, Lim K. “Caffeine as a lipolytic food component increases endurance performance in rats and athletes”. J Nutr Sci Vitaminol (Tokyo) 2001;47(2):139-46
  51. Bruce CR, Anderson ME, Fraser SF, Stepto NK, Klein R, Hopkins WG, Hawley JA. “Enhancement of 2000-m rowing performance after caffeine ingestion”. Med Sci Sports Exerc 2000;32(11):1958-63
  52. Anderson ME, Bruce CR, Fraser SF, Stepto NK, Klein R, Hopkins WG, Hawley JA. “Improved 2000-meter rowing performance in competitive oarswomen after caffeine ingestion”. Int J Sport Nutr Exerc Metab 2000;10(4):464-75
  53. Van Dongen HP, Price NJ, Mullington JM, Szuba MP, Kapoor SC, Dinges DF. “Caffeine eliminates psychomotor vigilance deficits from sleep inertia”. Sleep 2001;24(7):813-9
  54. Rogers PJ & Dernoncourt C. “Regular caffeine consumption: a balance of adverse and beneficial effects for mood and psychomotor performance”. Pharmacol Biochem Behav 1998;59(4):1039-45
  55. Lane JD, Phillips-Bute BG. “Caffeine deprivation affects vigilance performance and mood”. Physiol Behav 1998;65(1):171-5
  56. Wu,C.D.; Wei,G.X. (2002) Tea as a functional food for oral health. Nutrition 18, 443-444.
  57. Kim HK, Cheon BS, Kim YH, Kim SY, Kim HP. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity
  58. Yang F, de Villiers WJ, McClain CJ, Varilek GW. Green tea polyphenols block endotoxin-induced tumor necrosis factor-production and lethality in a murine model. J Nutr. 1998;128:2334-40.
  59. Varilek GW, Yang F, Lee EY et al. Green tea polyphenol extract attenuates inflammation in interleukin-2-deficient mice, a model of autoimmunity. J Nutr. 2001;131:2034-9.
  60. Haqqi TM, Anthony DD, Gupta S et al. Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc.Natl.Acad.Sci.U.S.A 1999;96:4524-9.
  61. Goto, K., Kanaya, S., Ishigami, T., and Hara, Y. (1999) The effects of tea catechins on fecal conditions of the elderly residents in a long-term care facility. J. Nutr. Sci. Vitaminol. 45, 135-141.
  62. Blaut, M., Schoefer, L., and Braune, A. (2003) Transformation of Flavonoids by Intestinal Microorganisms. Int. J. Vitam. Nutr. Res., 73 (2), 2003, 79–87.
  63. Yee,Y.K.; Koo,M.W.; Szeto,M.L. (2002) Chinese tea consumption and lower risk of Helicobacter infection. J Gastroenterol.Hepatol. 17, 552-5.
  64. Lee,K.M.; Yeo,M.; Choue,J.S.; Jin,J.H.; Park,S.J.; Cheong,J.Y.; Lee,K.J.; Kim,J.H.; Hahm,K.B. (2004) Protective Mechanism of Epigallocatechin-3-Gallate against Helicobacter pylori-Induced Gastric Epithelial Cytotoxicity via the Blockage of TLR-4 Signaling. Helicobacter. 9, 632-42.
  65. Rumpler W, et al (2001) “Oolong tea increases metabolic rate and fat oxidation in men” J. Nutr. 131 (11),: 2848 - 2852
  66. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. “Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans”. Am J Clin Nutr 1999 Dec;70(6):1040-5
  67. Hakim IA, Harris RB, Brown S, Chow HH, Wiseman S, Agarwal S, Talbot W. Effect of increased tea consumption on oxidative DNA damage among smokers: a randomized controlled study. J Nutr. 2003 Oct;133(10):3303S-3309S.
  68. Singleton VL & Rossi JA (1965) “Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents” Am. J Enol Viticult 16 (3), 144-158
  69. Shepherd M.J., Ibe F. “Flavonoids in UK Total Diet Samples” (1995) MAFF, CSL Report No. FD95/2
  70. Rice-Evans, C. (1999) Implications of the mechanisms of action of tea polyphenols as antioxidants in vitro for chemoprevention in humans. Proc.Soc.Exp Biol.Med 220, 262-266.
  71. Vinson, J. et al. Plant flavonoids, especially tea flavanols, are powerful antioxidants using an in vitro oxidation model for heart disease. Journal of Agriculture and Food Chemistry. 43:11:2800-2802, 1995.
  72. Leenen, R., Roodenburg, A. J., Tijburg, L. B., and Wiseman, S. A. (2000) A single dose of tea with or without milk increases plasma antioxidant activity in humans. Eur.J.Clin.Nutr. 54, 87-92.
  73. Al Suwaidi, J., Hamasaki, S., Higano, S. T., Nishimura, R. A., Holmes, D. R., and Lerman, A. (2000) Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 101, 948-954.
  74. Hodgson, J. M., Puddey, I. B., Burke, V., Watts, G. F., and Beilin, L. J. (2002) Regular ingestion of black tea improves brachial artery vasodilator function. Clin. Science 102, 195-201.
  75. Neumann, H. A., Carlsson, K., and Brom, G. H. (1992) Uptake and localisation of O-(beta-hydroxyethyl)-rutosides in the venous wall, measured by laser scanning microscopy. Eur.J Clin.Pharmacol. 43, 423-426.
  76. Niess AM, Dickhuth HH, Northoff H, Fehrenbach E. “Free radicals and oxidative stress in exercise--immunological aspects” Exerc Immunol Rev 1999;5:22-56
  77. Sen CK. Antioxidants in exercise nutrition. Sports Med 2001;31(13):891-908
  78. Konig D, Wagner KH, Elmadfa I, Berg A. Exercise and oxidative stress: significance of antioxidants with reference to inflammatory, muscular, and systemic stress. Exerc Immunol Rev 2001;7:108-33
  79. Ji LL Antioxidants and oxidative stress in exercise.. Proc Soc Exp Biol Med 1999 Dec;222(3):283-92
  80. Clarkson PM, Thompson HS. Antioxidants: what role do they play in physical activity and health? Am J Clin Nutr 2000 Aug;72(2 Suppl):637S-46S

Citations to Research on Omega-3 Oils

Conversion of ALA into DHA and EPA

  1. Goyens PL, Spilker ME, Zock PL, et al. Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses. J Lipid Res, 2005. 46:1474-83.
  2. David BC, Kris-Etherton PM. Achieving optimal essential fatty acid status in vegetarians: current knowledge and practical implications. Am J Clin Nutr, 2003. 78:640S-646S.
  3. Hussein N, Ah-Sing E, Wilkinson P, et al. Long-chain conversion of [13C] linoleic acid and alpha-linolenic acid in response to marked changed in their dietary intake in men. J LipidRes, 2005. 46:269-80.
  4. Gerster H. Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)? Int J Vitam Nutr Res, 1998. 68:159-73.
  5. Su HM, Huang MD, Saad NM, et al. Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res, 2001. 42:581-6.
  6. Burdge GC, Calder PC. Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod Nutr Dev, 2005. 45:581-97. PubMed Abstract
  7. Burdge GC. Alpha-linolenic acid metabolism in men and women: nutritional and biological implications. Curr Opin Clin Nutr Metab Care, 2004. 7:137-44.
  8. Brenna JT. Efficiency of conversion of alpha-linolenic acid to long-chain n-3 fatty acids in man. Curr Opin Clin Nutr Metab Care, 2002. 5:127-132.

Effects of DHA Supplementation/Ingestion in Adults

  1. Davidson MH, Maki KC, Kalkowski J, et al. Effects of docosahexaenoic acid on the serum lipoproteins with combined hyperlipidemia: a randomized, double-blind, placebo-controlled trial. J Am Coll Nutr. 1997; 16:236-243.
  2. Eriksson PS, Perfilieva E, Bjork-Eriksson T, et al. Neurogenesis in the adult human hippocampus. Nat Med. 1998; 4:1313-1317.
  3. Freedman SD, Katz MH, Parker EM, et al. A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in aftr/mice. Proc Natl Acad Sci USA. 1999; 96:13995-14000.
  4. Grimsgaard S, Bonaa KH, Hansen J-B, Nordoy A. Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. Am J Clin Nutr. 1997; 66:649-959.
  5. Horrocks LA, Yeo YK. Health benefits of docosahexaenoic acid. Pharma Res. 1999; 40:211-225.
  6. Lucas A, Stafford M, Morley R, et al. Efficacy and safety of long-chain polyunsaturated fatty acid supplementation of infant-formula milk: a randomized trial. Lancet 1999; 354:1948-1954.
  7. Madsen L, Rustan AC, Vaagenes H, et al. Eicosapentaenoic and docosahexaenoic acid affect mitochondrial and peroxisomal fatty acid oxidation in relation to substrate preference. Lipids 1999; 34:951-963.
  8. Martinez M, Vazquez E, Garcia-Silva MT, et al. Therapeutic effects of docosahexaenoic acid ethyl ester in patients with generalized peroxisomal disorders. Am J Clin Nutr. 2000; 71:376S-385S.
  9. Nelson GJ, Schmidt PS, Bartolini GL, et al. The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. Lipids 1997; 32:1129-1136.
  10. Soderberg M, Edlund C, Kristennson K, et al. Fatty acid composition of brain phospholipids in aging and Alzheimer's disease. Lipids 1991; 26:421-415.
  11. Stordy BJ. Dark adaptation, motor skills, docosahexaenoic acid, and dyslexia. Am J Clin Nutr. 2000; 71:323S-326S.